Oseltamivir-resistant h1n1 influenza virus: case report

Abstract

Swine flu is mainly caused by influenza virus strain H1N1. This strain of influenza has been found to cause seasonal flu. Animals are common source of influenza virus, in particular, pigs. Transmissions from animals to humans are reported on several occasions worldwide. These cases are usually mild to moderate in nature and are usually not fatal.

Here we describe a case of a healthy woman from Haripur, Pakistan, who presented in the Emergency Department of Quaid-e-Azam International Hospital, Islamabad and later developed a lethal course of H1N1influenza virus that resulted in her death, despite of aggressive management with Osaltemivir and Antibiotics in the Intensive care unit.

Osaltemivir resistance has emerged in many countries including Pakistan. There is a strong need for increasing surveillance and the laboratories that can test for antiviral resistance, particularly in a third world country like Pakistan.

Keywords: H1N1 Virus, Oseltamivir, Influenza A virus, Antiviral Resistance.