Clinical course, long-term outcomes, and Chemotherapy toxicity profile in B-cell Non-Hodgkin Lymphoma in children: single institution experience of Pakistan Authors Palwasha Rehman Department of Pediatric Oncology, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan Rabia Muhammad Wali Department of Pediatric Oncology, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan DOI: https://doi.org/10.47391/JPMA.3965 Abstract Objective: To analyse the disease presentation, clinical course and long-term outcomes of children diagnosed with B-cell non-Hodgkin lymphoma. Method: The retrospective descriptive study was conducted at the Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan and comprised data of patients diagnosed with B cell non-Hodgkin lymphoma between January 2012 and December 2016, with follow-up time of 4 years post-treatment. Data was collected from the institutional database. Data was analysed using SPSS 20. Results: Of the 286 patients, 217(75.6%) were males and 69(24.1%) were females. The overall mean age at presentation was 7.6±4.1 years (range: 1-16 years). Burkitt lymphoma was diagnosed in 194(67.8%) patients, and diffuse large B cell in 83(29.0%). Majority of patients had presented with stage III disease 159(55.6%). Complete remission was achieved in 173(60.5%) patients, while 90(31.5%) died during treatment. The 4-year overall survival observed was 67.1%, whereas event-free survival was 60.5%. Conclusion: Majority of the paediatric patients presented with extensive disease. Measures are needed for early recognition, identification, and prompt referral to paediatric cancer institute. Key Words: B cell origin, Children, Non-Hodgkin lymphoma, Outcome. Downloads Full Text Article Published 2022-09-15 How to Cite Rehman, P., & Wali, R. M. (2022). Clinical course, long-term outcomes, and Chemotherapy toxicity profile in B-cell Non-Hodgkin Lymphoma in children: single institution experience of Pakistan. Journal of the Pakistan Medical Association, 72(10), 1988–1993. https://doi.org/10.47391/JPMA.3965 More Citation Formats ACM ACS APA ABNT Chicago Harvard IEEE MLA Turabian Vancouver Download Citation Endnote/Zotero/Mendeley (RIS) BibTeX Issue Vol. 72 No. 10 (2022): OCTOBER Section ORIGINAL ARTICLE