Myoepithelial Carcinoma arising in a background of pleomorphic adenoma

Authors

  • Nausheen Yaqoob Department of Histopathology, The Indus Hospital, Karachi, Pakistan
  • Salima Mansoor Department of Histopathology, The Indus Hospital, Karachi, Pakistan https://orcid.org/0000-0001-7318-3053
  • Kanwal Aftab Department of Histopathology, The Indus Hospital, Karachi, Pakistan
  • Riyasat Ahmed Memon Department of Histopathology, The Indus Hospital, Karachi, Pakistan
  • Saba Jamal Department of Pathology, The Indus Hospital, Karachi, Pakistan

DOI:

https://doi.org/10.47391/JPMA.3528

Abstract

Carcinoma ex pleomorphic adenoma is a neoplasm of the salivary gland that causes 3.6% of salivary gland tumours and 12% of salivary gland malignancies. It is a myoepithelial or epithelial neoplasm that arises from pleomorphic adenoma, whether primary or recurrent. Historically carcinoma ex pleomorphic adenoma is considered a high-grade malignancy. Salivary duct carcinoma and high-grade adenocarcinoma are the histologic types that most commonly arise in the background of Pleomorphic adenoma. However, 15% of tumours arising in Pleomorphic adenoma are considered low grade and have sluggish growth. Low-grade carcinoma ex pleomorphic adenoma can be difficult to differentiate from cellular pleomorphic adenoma.

The case of a 56-year-old female patient who had neck swelling is being presented. The biopsy showed spindle cell component with mild atypia, invasion into surrounding tissue, and increased mitotic activity on the basis

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Published

2022-09-15

How to Cite

Yaqoob, N. ., Mansoor, S., Aftab, K., Memon, R. A., & Jamal, S. (2022). Myoepithelial Carcinoma arising in a background of pleomorphic adenoma. Journal of the Pakistan Medical Association, 72(10), 2105–2107. https://doi.org/10.47391/JPMA.3528

Issue

Section

CASE REPORT