Myoepithelial Carcinoma arising in a background of pleomorphic adenoma Authors Nausheen Yaqoob Department of Histopathology, The Indus Hospital, Karachi, Pakistan Salima Mansoor Department of Histopathology, The Indus Hospital, Karachi, Pakistan https://orcid.org/0000-0001-7318-3053 Kanwal Aftab Department of Histopathology, The Indus Hospital, Karachi, Pakistan Riyasat Ahmed Memon Department of Histopathology, The Indus Hospital, Karachi, Pakistan Saba Jamal Department of Pathology, The Indus Hospital, Karachi, Pakistan DOI: https://doi.org/10.47391/JPMA.3528 Abstract Carcinoma ex pleomorphic adenoma is a neoplasm of the salivary gland that causes 3.6% of salivary gland tumours and 12% of salivary gland malignancies. It is a myoepithelial or epithelial neoplasm that arises from pleomorphic adenoma, whether primary or recurrent. Historically carcinoma ex pleomorphic adenoma is considered a high-grade malignancy. Salivary duct carcinoma and high-grade adenocarcinoma are the histologic types that most commonly arise in the background of Pleomorphic adenoma. However, 15% of tumours arising in Pleomorphic adenoma are considered low grade and have sluggish growth. Low-grade carcinoma ex pleomorphic adenoma can be difficult to differentiate from cellular pleomorphic adenoma. The case of a 56-year-old female patient who had neck swelling is being presented. The biopsy showed spindle cell component with mild atypia, invasion into surrounding tissue, and increased mitotic activity on the basis ---Continue Downloads Full Text Article Published 2022-09-15 How to Cite Yaqoob, N. ., Mansoor, S., Aftab, K., Memon, R. A., & Jamal, S. (2022). Myoepithelial Carcinoma arising in a background of pleomorphic adenoma. Journal of the Pakistan Medical Association, 72(10), 2105–2107. https://doi.org/10.47391/JPMA.3528 More Citation Formats ACM ACS APA ABNT Chicago Harvard IEEE MLA Turabian Vancouver Download Citation Endnote/Zotero/Mendeley (RIS) BibTeX Issue Vol. 72 No. 10 (2022): OCTOBER Section CASE REPORT