Is Depression Dialyzable? Authors Sourabh Sharma Department of Nephrology, VMMC & Safdarjung Hospital, New Delhi, India Sanjay Kalra Department of Endocrinology, Bharti Hospital, Karnal, India; University Center for Research & Development, Chandigarh University, Mohali, India DOI: https://doi.org/10.47391/JPMA.25-13 Abstract Depression is a common and debilitating comorbidity inpatients with chronic kidney disease (CKD), particularlythose with end-stage kidney disease (ESKD, CKD stage 5).This association stems from a complex interplay ofbiological and psychosocial factors, including theaccumulation of uraemic toxins such as middlemolecules, chronic inflammation, and the psychologicalburden of disease progression. Initiation of dialysis hasbeen observed to alleviate depressive symptoms throughmultiple mechanisms: removal of uraemic toxins,improvement in physical health, and reduction inpsychosocial stressors. This article reviews thepathophysiological underpinnings of depression in CKD,explores the impact of dialysis on depressive symptoms,and evaluates whether depression can be considered a"dialyzable" entity. Keywords: chronic kidney disease, depression, dialysis,middle molecules, uremic toxins, anxiety, ESRD, mentalhealth Downloads Full Text Article Published 2025-01-26 How to Cite Sourabh Sharma, & Sanjay Kalra. (2025). Is Depression Dialyzable?. Journal of the Pakistan Medical Association, 75(02), 332–333. https://doi.org/10.47391/JPMA.25-13 More Citation Formats ACM ACS APA ABNT Chicago Harvard IEEE MLA Turabian Vancouver Download Citation Endnote/Zotero/Mendeley (RIS) BibTeX Issue Vol. 75 No. 02 (2025): FEBRUARY Section ADVANCES IN NEPHROLOGY License Copyright (c) 2025 Journal of the Pakistan Medical Association This work is licensed under a Creative Commons Attribution 4.0 International License.