Postpartum pituitary necrosis and hypopituitarism, a sequela of severe falciparum malaria in pregnancy – a case report Authors Moeez Ahmed Department of Medicine, Hearts International Hospital, Rawalpindi, Pakistan Shahid Ahmed Department of Endocrinology, Hearts International Hospital, Rawalpindi, Pakistan DOI: https://doi.org/10.47391/JPMA.20214 Keywords: Postpartum, hypopituitarism, falciparum malaria Abstract A 37 year old woman presented with a history of weakness and lethargy for many years. She had been amenorrhoeic for 5 years after a still birth at 37 weeks gestation, due to severe falciparum malaria. On examination, she appeared pale and lethargic, with a blood pressure of 100/70 mm Hg. Her systemic examination was unremarkable. Laboratory tests revealed low 9.00 am serum ACTH and cortisol levels, along with low free T4, FSH and LH levels. A short synacthen test showed an inadequate cortisol response at 30 minutes. MRI of the Pituitary gland displayed an empty sella. She was diagnosed with hypopituitarism due to postpartum pituitary necrosis, and was treated with hydrocortisone, thyroxine and sex hormone replacement therapy. The patient showed an excellent response to treatment. Keywords: Postpartum, hypopituitarism, falciparum malaria. Downloads Full Text Article Published 2025-01-26 How to Cite Ahmed, M., & Shahid Ahmed. (2025). Postpartum pituitary necrosis and hypopituitarism, a sequela of severe falciparum malaria in pregnancy – a case report. Journal of the Pakistan Medical Association, 75(02), 311–312. https://doi.org/10.47391/JPMA.20214 More Citation Formats ACM ACS APA ABNT Chicago Harvard IEEE MLA Turabian Vancouver Download Citation Endnote/Zotero/Mendeley (RIS) BibTeX Issue Vol. 75 No. 02 (2025): FEBRUARY Section CASE REPORT License Copyright (c) 2025 Journal of the Pakistan Medical Association This work is licensed under a Creative Commons Attribution 4.0 International License.