Gorham-Stout disease: a textbook presentation of a rare disease in Pakistan Authors Muhammad Ibrahim Department of Orthopaedic and Trauma, Rehman Medical Institute, Peshawar, Pakistan Muhammad Usman Department of Orthopaedic and Trauma, Rehman Medical Institute, Peshawar, Pakistan Hawwa Khan Department of Orthopaedic and Trauma, Rehman Medical Institute, Peshawar, Pakistan Faryal Javaid Department of Pathology, Rehman Medical Institute, Peshawar, Pakistan Maria Tasneem Department of Pathology, Rehman Medical Institute, Peshawar, Pakistan Zeeshan Khan Department of Orthopaedic and Trauma, Rehman Medical Institute, Peshawar, Pakistan DOI: https://doi.org/10.47391/JPMA.20212 Keywords: Gorham Stout Syndrome, Massive osteolysis, Rare disease Abstract Gorham-Stout disease is an exceptionally rare disease which is characterised by massive osteolysis of the bone, oedema, and in severe cases pleural effusion and chylothorax. Its aetiopathology is unknown, and no specific treatment has been modulated thus far. We report the case of a 17-year-old male with osteolysis in the bones of his entire left arm and persistent chylothorax. Due to the late presentation and patient’s desire for a better quality of life, amputation was the only choice left for treatment. This case was evaluated and treated at the Orthopaedic Surgery and Trauma department of Rehman Medical Institute in Peshawar, Pakistan. Key words: Gorham Stout Syndrome, Massive osteolysis, Rare disease. Downloads Full Text Article Published 2025-01-26 How to Cite Muhammad Ibrahim, Muhammad Usman, Hawwa Khan, Faryal Javaid, Maria Tasneem, & Zeeshan Khan. (2025). Gorham-Stout disease: a textbook presentation of a rare disease in Pakistan. Journal of the Pakistan Medical Association, 75(02), 307–310. https://doi.org/10.47391/JPMA.20212 More Citation Formats ACM ACS APA ABNT Chicago Harvard IEEE MLA Turabian Vancouver Download Citation Endnote/Zotero/Mendeley (RIS) BibTeX Issue Vol. 75 No. 02 (2025): FEBRUARY Section CASE REPORT License Copyright (c) 2025 Journal of the Pakistan Medical Association This work is licensed under a Creative Commons Attribution 4.0 International License.