Oxidative stress markers and brainstem auditory evoked potential in premenopausal, perimenopausal and postmenopausal females Authors Asma Ashraf Post Graduate Medical Institute, Lahore, Pakistan https://orcid.org/0009-0006-9549-2221 Seher Naeem Post Graduate Medical Institute, Lahore, Pakistan Madiha Akram Post Graduate Medical Institute, Lahore, Pakistan Muniza Saeed Post Graduate Medical Institute, Lahore, Pakistan DOI: https://doi.org/10.47391/JPMA.20077 Keywords: Menopause, Oxidative stress, Brainstem auditory evoked potential Abstract Objective: To measure biomarkers of oxidative stress and to determine hearing sensitivity by auditory brainstem response in premenopausal, perimenopausal and postmenopausal women. Method: The cross-sectional, comparative study was conducted in the departments of Physiology and Audiology at the Post-Graduate Medical Institute, Lahore, and the Lahore General Hospital, Lahore, Pakistan, from November 2020 to November 2021, and comprised healthy female subjects grouped into premenopausal group 1, perimenopausal group 2 and postmenopausal group 3 as per their menstrual history. Blood samples were taken for measuring biological indicators of oxidative damage, while auditory integrity was assessed by measuring absolute latencies of waves I, III, V and interpeak latency of waves III and V at an intensity of 80dB by performing brainstem auditory evoked potential. Data was analysed using SPSS 23. Results: Of the 45 subjects, 15(33.3%) with mean age 41.3±1.9 were in group 1, 15(33.3%) with mean age 46.7 ± 3.7 years were in group 2, and 15(33.3%) with mean age 55.8±2.7 years were in group 3. Significantly increased levels of thiobarbituric acid reactive substance were found in group 3 compared to groups 1 and 2 (p<0.05). Regarding auditory brainstem response, a significant increase was observed in absolute latencies of waves I, III, V and interpeak latency between waves III and V in group 3 compared to the other groups (p<0.05). Conclusion: Oxidative stress had a debilitating impact on hearing sensitivity related to the menopausal status of women. Key Words: Menopause, Oxidative stress, Brainstem auditory evoked potential. Downloads Full Text Article Published 2025-01-26 How to Cite Ashraf, A., Naeem, S., Akram, M., & Saeed, M. (2025). Oxidative stress markers and brainstem auditory evoked potential in premenopausal, perimenopausal and postmenopausal females. Journal of the Pakistan Medical Association, 75(02), 243–248. https://doi.org/10.47391/JPMA.20077 More Citation Formats ACM ACS APA ABNT Chicago Harvard IEEE MLA Turabian Vancouver Download Citation Endnote/Zotero/Mendeley (RIS) BibTeX Issue Vol. 75 No. 02 (2025): FEBRUARY Section RESEARCH ARTICLE License Copyright (c) 2025 Journal of the Pakistan Medical Association This work is licensed under a Creative Commons Attribution 4.0 International License.