Response to Carboplatin and Paclitaxel in the treatment of hereditary breast ovarian cancer syndrome (HBOC): a case report

Authors

  • Faisal Mehmood Department of Oncology, Combined Military Hospital, Lahore, Pakistan
  • Mumtaz Touseef Department of Medicine, Combined Military Hospital, Lahore, Pakistan
  • Amna Ashraf Department of Medicine, Combined Military Hospital, Lahore, Pakistan
  • Izza Ali Rai Department of Vascular Surgery, Combined Military Hospital, Lahore, Pakistan

DOI:

https://doi.org/10.47391/JPMA.20059

Keywords:

Hereditary breast ovarian cancer, Breast cancer, Ovarian cancer, HBOC, BRCA, PALB2, Chemotherapy, Carboplatin, Paclitaxel

Abstract

The co-occurrence of primary breast cancer and primary ovarian cancer is an exceptional hereditary phenomenon and results from inherent mutations in critical genes like BRCA1/2, PALB2, TP53, CHEK1, and ATM. We present here a unique case of hereditary breast-ovarian cancer syndrome (HBOC) reported in Combined Military Hospital, Lahore, Pakistan. It was marked by pathogenic variants in RAD51D, PALB2, CHEK1, and TP53 genes. Remarkably, the patient exhibited an outstanding response to the chemotherapy agents, Carboplatin and Paclitaxel. This dynamic treatment not only led to nearly complete remission of high-grade ovarian serous cancer but also triggered regression in grade-2 invasive ductal breast cancer after just a few rounds of chemotherapy. Consequently, what started as palliative care evolved into a curative triumph.

Keywords: Hereditary breast ovarian cancer, Breast cancer, Ovarian cancer, HBOC, BRCA, PALB2, Chemotherapy, Carboplatin, Paclitaxel.

Published

2024-11-17

How to Cite

Mehmood, F., Touseef, M., Ashraf, A., & Ali Rai, I. (2024). Response to Carboplatin and Paclitaxel in the treatment of hereditary breast ovarian cancer syndrome (HBOC): a case report. Journal of the Pakistan Medical Association, 74(12), 2184–2187. https://doi.org/10.47391/JPMA.20059

Issue

Section

CASE REPORT