Predictive value of neutrophil-lymphocyte ratio in assessing the outcomes of diabetic foot ulcer Authors Zia Ur Rehman Department of Vascular Surgery, Aga Khan University Hospital, Karachi, Pakistan Hafsa Shaikh Aga Khan University, Karachi, Pakistan Filza Bachani Department of Medicine, Aga Khan University Hospital, Karachi, Pakistan DOI: https://doi.org/10.47391/JPMA.10973 Keywords: Diabetic foot, Outcomes, Complications, Surgery Abstract Objective: To assess the correlation of neutrophil-lymphocyte ratio with clinical outcomes in diabetic foot ulcer cases. Method: The retrospective, cross-sectional, single-centre study was conducted at Section of Vascular Surgery, Aga Khan University Hospital, Karachi (Pakistan), and comprised data from January 2019 to January 2022 of diabetic foot inpatients of either gender aged at least 18 years. Un-hospital complications and outcomes were noted along with other data on a self-designed proforma. Diagnostic performance of neutrophil-lymphocyte ratio and its correlation with qualitative variables were assessed. Data was analysed using SPSS 26. Results: Of the 130 patients with mean age 60.13+/-11.75 years, 98(75.4%) were males. Surgical intervention was needed in 118(90.8%) cases, with below-knee amputation being the most frequent procedure 38(32.3%). Neutrophil-lymphocyte ratio >4 was significantly associated with a higher grade of diabetic foot ulcer, major amputation, and postoperative complications (p<0.0001) as well as with in-hospital (p=0.008) and 1-year mortality (p=0.01). Conclusion: Neutrophil-lymphocyte ratio could be potentially used as a sensitive and economically feasible biomarker for evaluating the prognosis of patients presenting with diabetic foot ulcers. Key Words: Diabetic foot, Outcomes, Complications, Surgery. Downloads Full Text Article Published 2024-11-17 How to Cite Zia Ur Rehman, Shaikh, H., & Bachani, F. (2024). Predictive value of neutrophil-lymphocyte ratio in assessing the outcomes of diabetic foot ulcer. Journal of the Pakistan Medical Association, 74(12), 2096–2100. https://doi.org/10.47391/JPMA.10973 More Citation Formats ACM ACS APA ABNT Chicago Harvard IEEE MLA Turabian Vancouver Download Citation Endnote/Zotero/Mendeley (RIS) BibTeX Issue Vol. 74 No. 12 (2024): DECEMBER Section RESEARCH ARTICLE License Copyright (c) 2024 Journal of the Pakistan Medical Association This work is licensed under a Creative Commons Attribution 4.0 International License.