Thromboembolic event in a patient of immune thrombocytopenic purpura: a case report Authors Maimoona Nazar 5th Year MBBS Student, Federal Medical College, Pakistan Institute of Medical Sciences, Islamabad, Pakistan Nasir Ashraf Department of Medicine, Pakistan Institute of Medical Sciences, Islamabad, Pakistan https://orcid.org/0009-0008-6907-2607 Laiba Sultan 5th Year MBBS Student, Federal Medical College, Pakistan Institute of Medical Sciences, Islamabad, Pakistan https://orcid.org/0009-0004-5150-4636 Laiba Sultan 5th Year MBBS Student, Federal Medical College, Pakistan Institute of Medical Sciences, Islamabad, Pakistan https://orcid.org/0009-0002-8423-2062 DOI: https://doi.org/10.47391/JPMA.10689 Keywords: Immune thrombocytopenia, Autoantibodies, Autoimmune, Thromboembolism, Corticosteroid therapy, Splenectomy Abstract Immune Thrombocytopenia Purpura (ITP) is an autoimmune disorder characterised by a low blood platelet count, which is attributed to both decreased megakaryocyte production in the bone marrow and the generation of autoantibodies causing platelet destruction in the spleen. Individuals with autoimmune conditions are highly susceptible to pulmonary embolism. This case involves a 39-year-old female with ITP who developed thromboembolisms. A comprehensive investigation into prothrombotic risk factors, including obesity, smoking, family history of thromboembolism, and ITP-related interventions such as prolonged corticosteroid use or splenectomy, revealed insignificant results, except for the patient's history of receiving corticosteroid therapy. Despite the disparate pathogenesis of thromboembolism (TE) and ITP, recent events of TE in ITP patients have been observed. This report underscores the potential life-threatening complications in ITP and aims to explore their causes and pathogenesis for ensuring optimised patient care. Key Words: Immune thrombocytopenia, autoantibodies, autoimmune, thromboembolism, corticosteroid therapy, splenectomy. Author Biographies Nasir Ashraf, Department of Medicine, Pakistan Institute of Medical Sciences, Islamabad, Pakistan Senior Registrar, Medicine Team 2, Pakistan Institute of Medical Sciences, Islamabad. Laiba Sultan, 5th Year MBBS Student, Federal Medical College, Pakistan Institute of Medical Sciences, Islamabad, Pakistan 5th Year MBBS, Federal Medical Callege, Pakistan Institute of Medical Sciences, Islamabad. Laiba Sultan, 5th Year MBBS Student, Federal Medical College, Pakistan Institute of Medical Sciences, Islamabad, Pakistan 5th Year MBBS, Federal Medical Callege, Pakistan Institute of Medical Sciences, Islamabad. Downloads Full Text Article Published 2025-01-26 How to Cite Nazar, M., Nasir Ashraf, Laiba Sultan, & Laiba Sultan. (2025). Thromboembolic event in a patient of immune thrombocytopenic purpura: a case report. Journal of the Pakistan Medical Association, 75(02), 355–357. https://doi.org/10.47391/JPMA.10689 More Citation Formats ACM ACS APA ABNT Chicago Harvard IEEE MLA Turabian Vancouver Download Citation Endnote/Zotero/Mendeley (RIS) BibTeX Issue Vol. 75 No. 02 (2025): FEBRUARY Section STUDENT'S CORNER CASE REPORT License Copyright (c) 2025 Journal of the Pakistan Medical Association This work is licensed under a Creative Commons Attribution 4.0 International License.