Favourable prognosis in metastatic adrenal carcinoma: an unexpected outcome

Authors

  • Imran Hassan Department of Family Medicine, Aga Khan University Hospital, Karachi, Pakistan
  • Aisha Sheikh Department of Medicine, Aga Khan University Hospital, Karachi, Pakistan

DOI:

https://doi.org/10.47391/JPMA.3494

Abstract

The case of a 45-year-old male patient diagnosed with European Network for the Study of Adrenal Tumours (ENSAT) criteria, stage IV adrenocortical carcinoma (ACC) with unexpectedly prolonged survival is being reported. The patient underwent resection of stage IV ACC and despite suboptimal adherence to postoperative mitotane and chemotherapy, had a prolonged survival spanning almost seven years. The possible reasons for such an outcome are discussed. ACC is a rare tumour with stage 4 disease known to be associated with a particularly grim prognosis. A low grade on histology (mitotic index 11-12 per 50 HPF) was likely responsible for the prolonged survival of our patient. Low grade disease may predict extended survival in stage IV ACC.

Keywords: adrenal cancers, adrenal cortex diseases, adrenal gland diseases, adrenal gland neoplasms.

Author Biographies

Imran Hassan, Department of Family Medicine, Aga Khan University Hospital, Karachi, Pakistan

Instructor

Aisha Sheikh, Department of Medicine, Aga Khan University Hospital, Karachi, Pakistan

Lecturer

Published

2022-09-15

How to Cite

Imran Hassan, & Aisha Sheikh. (2022). Favourable prognosis in metastatic adrenal carcinoma: an unexpected outcome. Journal of the Pakistan Medical Association, 72(10), 2101–2104. https://doi.org/10.47391/JPMA.3494

Issue

Section

CASE REPORT