Prognostic significance of D-dimer, neuron-specific enolase, and lactate dehydrogenase changes in patients with severe traumatic brain injury: a logistic regression analysis Authors Jing Xie Department of Neurosurgery, Baoding No.1 Central Hospital, Baoding, China Lu Zhang Department of Neurosurgery, Baoding No.1 Central Hospital, Baoding, China Ning Gan Department of Neurosurgery, Baoding No.1 Central Hospital, Baoding, China DOI: https://doi.org/10.47391/JPMA.11088 Keywords: severe traumatic brain injury, Neuron-specific enolase, D-dimer, Lactate dehydrogenase, Risk factors Abstract The retrospective study was conducted at Baoding No.1 Central Hospital, China, and comprised data from July 2021 to January 2023, and aimed at exploring the relationship of neuron-specific enolase, D-dimer and lactate dehydrogenase with prognosis in patients with serous traumatic brain injury. Data of 100 patients was categorised into favourable prognosis group A having 50(50%) patients and unfavourable prognosis group B having 50(50%) patients, and was compared with as many healthy controls in group C. Increase in neuron-specific enolase, D-dimer and lactate dehydrogenase concentrations was significantly elevated in groups A and B compared to group C (p<0.05), and in group B compared to group A (p<0.05). Key Words: Severe traumatic brain injury, Neuron-specific enolase, D-dimer, Lactate dehydrogenase, Risk factors. Downloads Full Text Article Published 2024-12-23 How to Cite Xie, J., Zhang, L., & Gan, N. (2024). Prognostic significance of D-dimer, neuron-specific enolase, and lactate dehydrogenase changes in patients with severe traumatic brain injury: a logistic regression analysis. Journal of the Pakistan Medical Association, 75(1), 103–104. https://doi.org/10.47391/JPMA.11088 More Citation Formats ACM ACS APA ABNT Chicago Harvard IEEE MLA Turabian Vancouver Download Citation Endnote/Zotero/Mendeley (RIS) BibTeX Issue Vol. 75 No. 1 (2025): JANUARY Section SHORT COMMUNICATION License Copyright (c) 2024 Journal of the Pakistan Medical Association This work is licensed under a Creative Commons Attribution 4.0 International License.