Acupuncture and cellular mechanisms: the role of foxo transcription factors in autophagy and senescence

Authors

  • Lizhi Zhou Comprehensive Department, Traditional Chinese Medicine Rehabilitation, China
  • Xuying Li Department of Traditional Chinese Medicine, Shiyan Taihe Hospital Affiliated to Hubei University of Medicine, China
  • Jinbi Ao Orthopaedic Rehabilitation Center, Wudangshan Hospital, Shiyan Taihe Hospital Affiliated to Hubei University of Medicine, China
  • Na Duan Department of Obstetrics, Shiyan Taihe Hospital Affiliated to Hubei University of Medicine, China

DOI:

https://doi.org/10.47391/JPMA.10423

Keywords:

Acupuncture therapy, Autophagy, Forkhead transcription factor O, Transcription factors, Cellular senescence, Aging, Traditional Chinese medicine

Abstract

The current narrative review was planned to elucidate the interplay between acupuncture, a cornerstone of Traditional Chinese Medicine, and the modulation of cellular mechanisms via Forkhead box O transcription factors, focussing on autophagy and cellular senescence. Autophagy, essential for cellular health, and cellular senescence, associated with aging and age-related diseases, are both significantly influenced by Forkhead box O transcription factors among other regulatory factors and pathways. These factors, known to diminish with age, play a pivotal role in promoting longevity. The current review analysed experimental models demonstrating acupuncture's capacity to activate Forkhead box O transcription factors, thereby inducing autophagy and reducing cellular senescence. Evidence from studies on human fibroblasts, aging animal models, obesity-induced insulin resistance, and osteoporosis corroborates the beneficial effects of acupuncture.

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Published

2024-11-17

How to Cite

Zhou, L., Li, X., Ao, J., & Duan, N. (2024). Acupuncture and cellular mechanisms: the role of foxo transcription factors in autophagy and senescence. Journal of the Pakistan Medical Association, 74(12), 2150–2154. https://doi.org/10.47391/JPMA.10423

Issue

Section

Narrative Review