GRADE-ADOLOPMENT of nephrology clinical practice guidelines and creation of referral algorithms for Pakistan Authors Ayesha Ali Third Year MBBS Student, Aga Khan University, Karachi, Pakistan Russell Seth Martins Centre for Clinical Best Practices, Clinical and Translational Research Incubator, Aga Khan University, Karachi, Pakistan Alina Pervez Centre for Clinical Best Practices, Clinical and Translational Research Incubator, Aga Khan University, Karachi, Pakistan Nashia Ali Rizvi Centre for Clinical Best Practices, Clinical and Translational Research Incubator, Aga Khan University, Karachi, Pakistan Mohsin Ali Mustafa Centre for Clinical Best Practices, Clinical and Translational Research Incubator, Aga Khan University, Karachi, Pakistan Sonia Yaqub Department of Nephrology, Aga Khan University, Karachi, Pakistan. DOI: https://doi.org/10.47391/JPMA.10192 Keywords: Chronic Kidney Disease, Clinical Practice Guideline, Referral Abstract Objective: To develop evidence-based local clinical practice guidelines and primary care referral pathways for general physicians to help streamline the management of glomerular diseases and diabetes in chronic kidney disease patients in Pakistan. Method: The study was conducted from October 2021 to February 2023 at the Centre for Clinical Best Practices, Aga Khan University Hospital, Karachi, in collaboration with the AKUH Section of Nephrology. Two source guidelines were selected by the local nephrologists after a thorough literature review on PubMed and Google Scholar. GRADE-ADOLOPMENT approach was used to adopt, adapt or exclude recommendations from the source guidelines in order to create the local clinical practice guidelines. Recommendations from the local clinical practice guidelines were used to create the primary care referral pathways. Results: Management guidelines for glomerular diseases and diabetes in chronic kidney disease and two primary care referral pathways for the management and timely referral of the patients were created for general physicians to follow in Pakistan. Conclusion: On the basis of two source guidelines, evidence-based local clinical practice guidelines and primary care referral pathways for general physicians were developed for general physicians in Pakistan for a smooth referral process. Key Words: Nephrology, Diabetes, Renal Insufficiency, Chronic, Health Care Downloads Full Text Article Published 2024-12-23 How to Cite Ali, A., Russell Seth Martins, Alina Pervez, Nashia Ali Rizvi, Mohsin Ali Mustafa, & Sonia Yaqub. (2024). GRADE-ADOLOPMENT of nephrology clinical practice guidelines and creation of referral algorithms for Pakistan. Journal of the Pakistan Medical Association, 75(1), 156–163. https://doi.org/10.47391/JPMA.10192 More Citation Formats ACM ACS APA ABNT Chicago Harvard IEEE MLA Turabian Vancouver Download Citation Endnote/Zotero/Mendeley (RIS) BibTeX Issue Vol. 75 No. 1 (2025): JANUARY Section STUDENT'S CORNER INNOVATION License Copyright (c) 2024 Journal of the Pakistan Medical Association This work is licensed under a Creative Commons Attribution 4.0 International License.